MRI Relaxation Rates: A Quantitative Approach to Track Tumour Cells Expressing MagA
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منابع مشابه
Longitudinal Monitoring of Stem Cell Grafts In Vivo Using Magnetic Resonance Imaging with Inducible Maga as a Genetic Reporter
PURPOSE The ability to longitudinally monitor cell grafts and assess their condition is critical for the clinical translation of stem cell therapy in regenerative medicine. Developing an inducible genetic magnetic resonance imaging (MRI) reporter will enable non-invasive and longitudinal monitoring of stem cell grafts in vivo. METHODS MagA, a bacterial gene involved in the formation of iron o...
متن کاملBiophysical features of MagA expression in mammalian cells: implications for MRI contrast
We compared overexpression of the magnetotactic bacterial gene MagA with the modified mammalian ferritin genes HF + LF, in which both heavy and light subunits lack iron response elements. Whereas both expression systems have been proposed for use in non-invasive, magnetic resonance (MR) reporter gene expression, limited information is available regarding their relative potential for providing g...
متن کاملCharacterization of Maga Expression and Iron Uptake in P19 Cells: Implications for Use as a Gene-Based Contrast Agent
.............................................................................................................................. II Acknowledgments ............................................................................................................. III List of Tables ................................................................................................................. VIII Lis...
متن کاملQuantitative Analysis of Relaxation Rate Dependence on Interecho Time in MagA-expressing, Iron-labeled Cells
II CO-AUTHORSHIP STATEMENT III
متن کاملMS-1 magA
Bacterial genes involved in the biomineralization of magnetic nanoparticles in magnetotactic bacteria have recently been proposed as reporters for magnetic resonance imaging (MRI). In such systems, the expression of the bacterial genes in mammalian cells purportedly leads to greater concentrations of intracellular iron or the biomineralization of iron oxides, thus leading to an enhancement in r...
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تاریخ انتشار 2016